THIS COURSE MAY BE TAKEN INDIVIDUALLY OR AS part of THE PROFESSIONAL CERTIFICATE PROGRAM IN BIOTECHNOLOGY & LIFE SCIENCES.
Fermentation Technology is the longest-run course in the MIT Professional Education catalog. It has been offered continuously for more than 50 years. This course emphasizes the application of biological and engineering principles to problems involving microbial, mammalian, and biological/biochemical systems. The aim of the course is to review fundamentals and provide an up-to-date account of current knowledge in biological and biochemical technology. The lectures will emphasize and place perspectives on biological systems with industrial practices.
This course has made some major additions, modifications, and revisions in the course topics and course contents over the past few years. In recognition of the increasing number of attendees from non-pharmaceutical industries, the instructors are balancing the course to provide equal emphasis on mammalian and microbial technologies. More than half of the lecturers are currently working in industry or have industrial experience.
- Examine the application of biological and engineering principles to problems involving microbial, mammalian, and biological/biochemical systems.
- Recognize the fundamentals of fermentation technology.
- Describe current knowledge in biological and biochemical technology, with a focus on industrial practices.
- Comprehend growth and metabolism, genetics and metabolic engineering in the age of genomics, the biological basis for monitoring bioprocesses including process analytical technology, and applications of the modern biological concepts in bioprocess developments.
- Examine eukaryotic and prokaryotic protein expression relevant to industrial practice, including post-translational modifications (esp. protein glycosylation).
- Assess power requirements in bioreactors, modeling of bioprocesses, traditional and new concepts in bioprocess monitoring, and the biological basis for industrial fermentations and cell cultures.
- Distinguish bioreactor operations in bacteria and mammalian cell systems, oxygen transfer and shear in bioreactors, process improvement through metabolic manipulations, and scale-up of bioreactors such as bacterial, yeast, and mammalian cells.
- Analyze the bioprocess paradigm: Scale-down, bioprocess simulation and economics, sterilization, and bioburden in biological manufacturing.
- Examine considerations in bioprocess simulation and economics, sterilization in biological manufacturing, and clinical implications of bioprocesses.
Who Should Attend
The course is intended for engineers, biologists, chemists, microbiologists, and biochemists who are interested in the areas of biological systems in prokaryotic and eukaryotic hosts. It is desirable that individuals enrolled be familiar with some of the general aspects of modern biology, genetics, biochemical engineering, and biochemistry. Some general knowledge of mathematics is also desirable for dealing with the engineering aspects of the course.
Class begins at 8:30 am on Monday and at 9:00 am the rest of the week. Class runs until 5:00 - 5:30 pm each day (variable) except for Friday when it ends at 12:30 pm.
Special events include a reception for course participants and faculty on Monday night and a dinner on Thursday evening. All evening activities are included in the tuition.
Lectures will cover the following topics:
- Growth and metabolism
- Molecular biology in bioprocess developments
- Bioprocess concepts in mammalian cell culture technology
- Protein expression in bacterial and mammalian cells: basic concepts and methods for improvements
- Post translational modifications: protein glycosylation
- Biological basis for industrial fermentations and cell cultures
- Power requirements in bioreactors
- Oxygen transfer and shear in bioreactors
- Bioreactor operations in bacterial and mammalian cell systems
- Modeling and traditional bioprocess monitoring
- Scale-up of bioreactors: bacteria, yeast, and mammalian cells
- Media and air sterilization
- Process analytical technology
- Clinical implications of bioprocesses
- Bioprocess simulation and economics
Course materials will be issued on the first day of class – no advanced preparation is necessary. Electrical power is available in the lecture hall.
- Dr. Daniel I.C. Wang
- Dr. Neal Connors
- Dr. Charles L. Cooney
- Dr. Robert D. Kiss
- Dr. James C. Leung
- Dr. J. Christopher Love
- Dr. Morris Z. Rosenberg
Links & Resources
The type of content you will learn in this course, whether it's a foundational understanding of the subject, the hottest trends and developments in the field, or suggested practical applications for industry.
How the course is taught, from traditional classroom lectures and riveting discussions to group projects to engaging and interactive simulations and exercises with your peers.
What level of expertise and familiarity the material in this course assumes you have. The greater the amount of introductory material taught in the course, the less you will need to be familiar with when you attend.