Bernhardt Trout Pic

Bernhardt L. Trout

Professor of Chemical Engineering, MIT

Bernhardt L. Trout is the Raymond F. Baddour, ScD, (1949) Professor of Chemical Engineering at MIT. He received his S.B. and S.M. degrees from MIT and his Ph.D. from the University of California at Berkeley. In addition, he performed post-doctoral research at the Max-Planck Institute.

Trout’s research focuses on the development of advanced manufacturing processes and rational tools for formulation and product design, primarily liquid formulations, but also lyophilized formulations. A major aspect of his research focuses on developing both microscopic and macroscopic models to design stable formulations efficiently. In 2007, with several colleagues from MIT, he set up the Novartis-MIT Center for Continuous Manufacturing, a $85 million partnership with the objective of transforming pharmaceutical manufacturing. Among other outputs, this led in 2011 to the first end-to-end fully integrated and automated pharmaceutical process (bench scale). He was also Co-Chair of the Singapore-MIT Alliance Program on Chemical and Pharmaceutical Engineering. In addition to Novartis, he has worked with many other pharmaceutical companies in research or consulting. He has also developed a host of computational methods for the design of biologics products taking into account developability and manufacturability and continues to work in the field of continuous manufacturing. He recently started a project with the FDA on a continuous lyophilization process. In addition, he is Co-Chair of the International Symposium on Continuous Manufacturing of Pharmaceuticals. He has published over 200 papers and has 18 patents issued or pending.

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