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Fermentation Technology is the longest-run course in the MIT Professional Education catalog. It has been offered continuously for more than 40 years. This course emphasizes the application of biological and engineering principles to problems involving microbial, mammalian, and biological/biochemical systems. The aim of the course is to review fundamentals and provide an up-to-date account of current knowledge in biological and biochemical technology. The lectures will emphasize and place perspectives on biological systems with industrial practices.
This course has made some major additions, modifications, and revisions in the course topics and course contents over the past few years. In recognition of the increasing number of attendees from non-pharmaceutical industries, the instructors are balancing the course to provide equal emphasis on mammalian and microbial technologies. More than half of the lecturers are currently working in industry or have industrial experience.
- Examine the application of biological and engineering principles to problems involving microbial, mammalian, and biological/biochemical systems.
- Recognize the fundamentals of fermentation technology.
- Describe current knowledge in biological and biochemical technology, with a focus on industrial practices.
- Comprehend growth and metabolism, genetics and metabolic engineering in the age of genomics, the biological basis for monitoring bioprocesses including process analytical technology, and applications of the modern biological concepts in bioprocess developments.
- Examine eukaryotic and prokaryotic protein expression relevant to industrial practice, including post-translational modifications (esp. protein glycosylation).
- Assess power requirements in bioreactors, modeling of bioprocesses, traditional and new concepts in bioprocess monitoring, and the biological basis for industrial fermentations and cell cultures.
- Distinguish bioreactor operations in bacteria and mammalian cell systems, oxygen transfer and shear in bioreactors, process improvement through metabolic manipulations, and scale-up of bioreactors such as bacterial, yeast, and mammalian cells.
- Analyze the bioprocess paradigm: Scale-down, bioprocess simulation and economics, sterilization, and bioburden in biological manufacturing.
- Examine considerations in bioprocess simulation and economics, sterilization in biological manufacturing, and clinical implications of bioprocesses.
Who Should Attend:
The course is intended for engineers, biologists, chemists, microbiologists, and biochemists who are interested in the areas of biological systems in prokaryotic and eukaryotic hosts. It is desirable that individuals enrolled be familiar with some of the general aspects of modern biology, genetics, biochemical engineering, and biochemistry. Some general knowledge of mathematics is also desirable for dealing with the engineering aspects of the course.
Lectures will cover the following topics:
- Growth and metabolism
- Molecular biology in bioprocess developments
- Bioprocess concepts in mammalian cell culture technology
- Protein expression in bacterial and mammalian cells: basic concepts and methods for improvements
- Post translational modifications: protein glycosylation
- Biological basis for industrial fermentations and cell cultures
- Power requirements in bioreactors
- Oxygen transfer and shear in bioreactors
- Bioreactor operations in bacterial and mammalian cell systems
- Modeling and traditional bioprocess monitoring
- Scale-up of bioreactors: bacteria, yeast, and mammalian cells
- Media and air sterilization
- Process analytical technology
- Clinical implications of bioprocesses
- Bioprocess simulation and economics
Course materials will be issued on the first day of class – no advanced preparation is necessary. Electrical power is available in the lecture hall.
Dr. Neal Connors, Consultant, Phoenix BioConsulting, LLC
Dr. Charles L. Cooney, Robert T. Haslam (1911) Professor of Chemical and Biochemical Engineering, Department of Chemical Engineering and the Faculty Director of the Deshpande Center for Technological Innovation at MIT
Dr. Robert D. Kiss, Director, Late Stage Culture Development, Genentech, Inc., S. San Francisco, CA
Dr. Kristala L. Jones Prather, Associate Professor, Department of Chemical Engineering, MIT
Dr. James C. Leung, Adjunct Associate Professor, Northeastern University; Visiting Scientist, Department of Biology, MIT
Dr. J. Christopher Love, Associate Professor, Department of Chemical Engineering, MIT
Dr. Morris Z. Rosenberg, Consultant, MRosenberg BioPharma Consulting
Class begins at 8:30 am on Monday and at 9:00 am the rest of the week. Class runs until 5:00 - 5:30 pm each day (variable) except for Friday when it ends at 12:30 pm.
Special events include a reception for course participants and faculty on Monday night and a dinner on Thursday evening. All evening activities are included in the tuition.
MICROBIOLOGIST, DUGWAY PROVING GROUND (DPG), U.S. ARMY
"I would definitely recommend this course to colleagues. In fact, I already have. I would recommend it because of its prominence in the pharmaceutical community... [T]his course is considered the very best in fermentation by word of mouth. It doesn't hurt that it is offered by the most prominent technological University in the country."
ASSOCIATE SCIENTIST, GLAXOSMITHKLINE BIOLOGICAL, NORTH AMERICA
"It's a great overview of fermentation theories incorporating all aspects from research down to manufacturing functions. The presenters are all top-notch and knew how to keep their presentation interesting and engaging."
PROJECT MANAGER, EPITOPIX
"It really passes the fundamentals of fermentation and gets into the real world of analytical measurement, scale-up, media formulation and the theory behind applications."
TECHNOLOGY ENGINEER, WYETH PHARMACEUTICAL
"I felt like the course was well organized, was a good blend of biology and engineering, and has a good balance of practical experience."
PROCESS ENGINEER II, NOVARTIS
"The course covered a broad range of fermentation technology and engineering design. I believe all were able to take something away from the course and directly apply it to their daily roles, as well as learn something new about applications of fermentation technologies."
SALES OPERATIONS MANAGER, FINESSE SOLUTIONS
"Instructors provided a broad range of experience both in industry and academia. Went beyond the curriculum and provided real-world examples."
MICROBIOLOGY TECHNICIAN, LOGOS TECHNOLOGIES, INC.
"Got to learn a great deal about the aspects of both mammalian and microbial cells and some of the challenges involved in fermentation of both cell types. Gained new knowledge and appreciation for cell fermentation that directly applies to the work I perform each day. With my new knowledge, I will be able to take on more duties and help ease the load of our current fermentation engineers, as well as bridging the gap between the genetic engineering and strain development side of things with the aspects of scaling up fermentations from shake flasks to bio-reactors."
MANUFACTURING ENGINEER, VALENT BIOSCIENCES
"Planning, maintenance, manufacturing, and process engineers could all benefit from this course. Because of the broad range of topics and coverage of new technology, a higher level unit manager (esp. engineering) could benefit."
AUTOMATION ENGINEER, GENENTECH
"This course allows me to ask better questions when I develop automation control solutions for my manufacturing science counterparts. This will also allow me to predict concerns from when products are transitioned to our site for the first time."
Dr. Daniel I.C. Wang is Institute Professor of Chemical Engineering at MIT. He holds a Bachelor of Science and a Master of Science degree in Biochemical Engineering from MIT and a doctorate in Chemical Engineering from the University of Pennsylvania. He is the recipient of numerous awards from the American Chemical Society, the American Institute of Chemical Engineers, and from schools here and abroad. He has been elected to the National Academy of Engineering and the American Institute of Medical and Biomedical Engineering. He has twice received Outstanding Teaching Awards at MIT and is a member of the Editorial Board of Biotechnology and Bioengineering, Comprehensive Biotechnology, Advances in Biotechnology, Genetic Engineering News, and World Scientific Publishing Life Sciences.
His publications comprise 250+ papers, five books and 15 patents.
This course was developed under the leadership of Prof. Daniel I. C. Wang. While he no longer takes an active role in instruction, he does continue to stay involved in the role of course co-director.
Kristala Jones Prather is an Associate Professor of Chemical Engineering at MIT and an investigator in the multi-institutional Synthetic Biology Engineering Research Center (SynBERC) funded by the National Science Foundation (USA). She received an S.B. degree from MIT in 1994 and Ph.D. from the University of California, Berkeley (1999), and worked four years in BioProcess Research and Development at the Merck Research Labs (Rahway, NJ). Prather is the recipient of a Camille and Henry Dreyfus Foundation New Faculty Award (2004), an Office of Naval Research Young Investigator Award (2005), a Technology Review "TR35" Young Innovator Award (2007), a National Science Foundation CAREER Award (2010), and the Biochemical Engineering Journal Young Investigator Award (2011). She has been recognized for excellence in teaching with the C. Michael Mohr Outstanding Faculty Award for Undergraduate Teaching in the Dept. of Chemical Engineering (2006), the MIT School of Engineering Junior Bose Award for Excellence in Teaching (2010), and through appointment as a MacVicar Faculty Fellow (2014), the highest honor given for undergraduate teaching at MIT.
Professor Prather has co-authored more than 75 manuscripts and two book chapters, and has five issued patents with several additional applications pending.
Dr. Neal Connors is the founder and a consultant at Phoenix BioConsulting, LLC. He received his BS in Biology from Norwich University in 1984 and his Ph.D. in Microbiology from The Ohio State University in 1991. From 1991 to 2008, he was a member of the Bioprocess R&D department of Merck & Co., Inc. rising to the level of Senior Investigator. His industrial microbiology experience is diverse: bioprocess development for renewable chemicals, fermentation and strain improvement for the production of anti-bacterial and anti-fungal natural products (e.g. Cancidas®), heterologous protein production using microbial fermentation or mammalian cell culture, whole-cell biocatalysis for the production of chiral intermediates. He has worked at all experimental scales, from well-plate and shake flask to lab and pilot fermentor scales. Dr. Connors is a contributing author on numerous peer reviewed papers, book chapters, patents, and published abstracts. He is also a sought-after seminar speaker at conferences and universities and currently lectures in the presitigous MIT Fermentation Technology summer course.
Dr. Connors is a member of the Society for Industrial Microbiology and Biotechnology and served as President (2011-2012) and Director (2006-2009). He also serves on the editorial boards of two peer-reviewed journals: Journal of Industrial Microbiology and Biotechnology (Springer) and Enzyme and Microbial Technology (Elsevier).
Charles L. Cooney is Robert T. Haslam Professor Emeritus in the MIT Department of Chemical Engineering. Cooney obtained his bachelor’s degree in Chemical Engineering from the University of Pennsylvania and his master’s degree and PhD degree in Biochemical Engineering from MIT. After working briefly at the Squibb Institute for Medical Research, he joined the faculty of MIT as an Assistant Professor in 1970 and has been a full Professor since 1982. He has received the 1989 Gold Medal of the Institute of Biotechnological Studies (London); the Food, Pharmaceutical and Bioengineering Award from the American Institute of Chemical Engineers; and the James Van Lanen Distinguished Service Award from the American Chemical Society’s Division of Microbial and Biochemical Technology, and was elected to the American Institute of Medical and Biochemical Engineers. He serves as a consultant to and/or director of a number of biotech and pharmaceutical companies and is on several boards of professional journals.
Dr. Robert D. Kiss is a Distinguished Engineer and Senior Director of BioProcess Development at Genentech. He received his BS in Chemical Engineering from the University of California, Davis, and then his MS and PhD degrees from MIT. His areas of focus within the industry have included media/process optimization and product quality control (especially protein glycosylation), barriers to virus contamination of mammalian cultures, and scale-up/scale-down strategies.
J. Christopher Love is an Associate Professor of Chemical Engineering at the Koch Institute for Integrative Cancer Research at MIT. He is also an Associate Member of the Broad Institute, and an Associate Member at the Ragon Institute of MGH, MIT, and Harvard. Love earned a BS in chemistry from the University of Virginia and a PhD in physical chemistry at Harvard University under the supervision of George Whitesides. Following completion of his doctoral studies, he extended his research into immunology at Harvard Medical School with Hidde Ploegh from 2004-2005, and at the Immune Disease Institute from 2005-2007. Dr. Love was a W.M. Keck Distinguished Young Scholar for Medical Research and a Dana Scholar for Human Immunology in 2009, a Life Sciences Research Foundation Postdoc Fellow (Gilead Sciences) in 2004, and a National Defense Science and Engineering Graduate Fellow from 1999-2002. He was also awarded the Foresight Distinguished Student Award in Nanotechnology in 2000. Love is also a Camille Dreyfus Teacher-Scholar.
Dr. Morris Rosenberg is founder and a consultant at MRosenberg BioPharma Consulting. He has over 25 years experience in the development of therapeutic agents to treat a variety of human diseases. He has participated in the development and launch of Adcetris, Avonex, Angiomax, Xigris, and Forteo. He played a key role over the past decade, as part of the executive management team at Seattle Genetics, in building a commercial biopharmaceutical company focused on the development of antibody-drug conjugate technology for the treatment of cancer and autoimmune disorders.
This course takes place on the MIT campus in Cambridge, Massachusetts. We can also offer this course for groups of employees at your location. Please complete the Custom Programs request form for further details.
|Fundamentals: Core concepts, understandings, and tools (35%)||35|
|Latest Developments: Recent advances and future trends (15%)||15|
|Industry Applications: Linking theory and real-world (50%)||50|
|Lecture: Delivery of material in a lecture format (90%)||90|
|Discussion or Groupwork: Participatory learning (10%)||10|
|Introductory: Appropriate for a general audience (10%)||10|
|Specialized: Assumes experience in practice area or field (70%)||70|
|Advanced: In-depth explorations at the graduate level (20%)||20|